Fantasy for me.
Horror (Some WoD, Cthulhu) require good DMing and regular play for the atmosphere, and as much as I enjoy good Horror RPG, I get to play far too little...
I always found SF and Post-Apo to be a little bland... may be just me.
Also, I got scared out of Cyberpunk by high mortality rates (Cyberpunk) and/or icky rule sets (Shadowrun)...
Never played Supers, but it sounds fun to do...